Missing Data in Clinical Studies

Missing data imputation in multivariable time series data

Multivariate time series data are found in a variety of fields such as bioinformatics, biology, genetics, astronomy, geography and finance. Many time series datasets contain missing data. Multivariate time series missing data imputation is a challenging topic and needs to be carefully considered before learning or predicting time series. Frequent researches have been done on the use of diffe...

Missing Data in Repeated Measurement Studies

Meta-analysis of studies with missing data.

SUMMARY Consider a meta-analysis of studies with varying proportions of patient-level missing data, and assume that each primary study has made certain missing data adjustments so that the reported estimates of treatment effect size and variance are valid. These estimates of treatment effects can be combined across studies by standard meta-analytic methods, employing a random-effects model to a...

DEA with Missing Data: An Interval Data Assignment Approach

In the classical data envelopment analysis (DEA) models, inputs and outputs are assumed as known variables, and these models cannot deal with unknown amounts of variables directly. In recent years, there are few researches on handling missing data. This paper suggests a new interval based approach to apply missing data, which is the modified version of Kousmanen (2009) approach. First, the prop...

Missing data methods in Mendelian randomization studies with multiple instruments.

Mendelian randomization studies typically have low power. Where there are several valid candidate genetic instruments, precision can be gained by using all the instruments available. However, sporadically missing genetic data can offset this gain. The authors describe 4 Bayesian methods for imputing the missing data based on a missing-at-random assumption: multiple imputations, single nucleotid...